Technology Review: Chinese scientists are creating CRISPR babies

It was the invention of a powerful gene editing tool, CRISPR, which is cheap and easy to deploy, that made the birth of humans genetically modified in an in-vitro fertilization (IVF) center a theoretical possibility.

Now, it appears it may already be happening.

According to Chinese medical documents posted online this month (here and here), a team at the Southern University of Science and Technology, in Shenzhen, has been recruiting couples in an effort to create the first gene-edited babies. They planned to eliminate a gene called CCR5 in order to render the offspring resistant to HIV, smallpox, and cholera. …

It is unclear if any children have been born. The scientist behind the effort, Jiankui He, did not reply to a list of questions about whether the undertaking had produced a live birth. Reached by telephone he declined to comment.

However, data submitted as part of the trial listing shows genetic tests have been carried out on fetuses as late as 24 weeks, or six months. It’s not known if those pregnancies were terminated, carried to term, or are ongoing.

It’s a popular meme that a China unencumbered by Judeo-Christian morality/superstitions (cross out as appropriate) will be more open to transhumanist technology.

For instance, here is a typical statement of this argument from my friend Hank Pellissier: East Asia is More “Transhumanist” than the USA & Europe

See also Darryl Macer (2012): Ethical Consequences of the Positive Views of Enhancement in Asia

But not so fast.

Just one day later comes this news – The Chinese scientist who claims he made CRISPR babies is under investigation:

On Sunday, the Shenzhen City Medical Ethics Expert Board said it would begin an investigation of He’s research and released a statement saying that HorMoniCare “according to our findings … never conducted the appropriate reporting according to requirements.” The former medical director of the private hospital, Jiang Su-Qi, told Southern Capital News, he had no recollection of approving He’s research while he was on its ethics committee.

“These two children are the guinea pigs. They will go through their whole maturing process having not understood the risks ahead of time,” said Liu Yan of Peking University Molecular Medicine Research Center.

The president of He’s university called an emergency gathering of researchers connected to the project. “This has nothing to do with SUST, the research wasn’t conducted at SUST, and the researchers are currently suspended without pay,” said SUST president Chen Yi, according to Chinese media reports. According to the school’s biology department the research “seriously violates ethical and academic standards and regulations.”

A 2003 guidance to Chinese IVF clinics prohibits the transfer of genetically-modified embryos to start a pregnancy. He’s American media spokesman, Ryan Ferrell, did not respond to questions about the legality of the project.

It remains unclear where He carried out his research and who paid for it. “He has explained to me that he electively went on leave years ago to focus full-time on research and not teach,” Farrell said. …

Separately, a group of 122 Chinese academics and scientists put out a statement condemning He’s research and calling on authorities to establish legal governance over gene-editing. “This presents a major blow to the image and development of Chinese life sciences on the global stage,” they said. “It is extremely unfair for the many honest and sincere scholars, working to adhere to moral practices in the sciences.”

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In reality, I’m not 100% sure this stereotype is merited.

1. The original Tech Review report contains to a link to a recent poll commissioned by the Global Times, which shows that Chinese support for genetic tinkering is remarkably similar to American numbers.

About 62% of Chinese support genetic edits to children likely to develop a fatal genetic disease, versus 60% of Americans who would change a baby’s genes to reduce of the risk of a serious disease that could occur over the child’s life.

However, only about 23% of Chinese would support gene editing for improving intelligence, versus 19% of Americans.

For all intents and purposes, these numbers are identical, so contrary to previous thinking, we can no longer expect Chinese public opinion to push us towards CRISPR-transhumanism.

Ultimately, it will be entirely up to the CPC.

2. China actually bans human germline modification, though only at the level of guidelines, not legislation, as in Europe and the Anglosphere minus USA.

map-world-law-human-germline-modification

The US situation is a regulatory morass, but formally speaking, it is freer than China.

Funnily enough, of the major countries, only Russia has an “ambiguous” position (though I suspect largely on account of nobody having thought about it yet, considering its extremely weak position in the bioscience sector).

3. You may be surprised by this, but despite the weekly SJW scandals, there is greater acceptance of evolutionary approaches to human behavior amongst North American social scientists and anthropologists than in any other region of the planet apart from Australasia.

In fairness, East Asians also do pretty well by global standards.

There is lower acceptance of it in Eastern Europe (Lysenkoism dies hard), and extremely low acceptance in the Middle East (figures).

This may perhaps also be taken as a sort of proxy on how open the scientific establishments in various countries will be to things like CRISPR babies.

Biologists are famously cucked among scientists, even in China, yes. My guess is that there’s too many women in the discipline. https://t.co/vL1GWhbwo6

— Spandrell (@thespandrell) November 26, 2018

Anyway, what I’m saying is, one shouldn’t necessarily expect the biosingularity to originate in East Asia. While before I thought China had much better prospects than the US, now I rate them about equally.

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If some kind of global moratorium goes ahead, the chances of seeing a biosingularity happen will obviously fall.

This introduces some interesting considerations.

(1) Defections. I have often noted that any country that started genetic editing for IQ at a sufficiently mass level could gain a massive strategic advantage, even if it only managed to keep the program under wraps for a few years while the other countries debate bioethics. This strategic advantage will come by dint of the extremely unbalanced positive effects on economic dynamism and scientific productivity of “smart fractions.” Inject one or two orders of magnitude more of them into the labor pool a decade or two in advance of the rest of the world and you could develop a near insurmountable lead, like Britain did after the Industrial Revolution.

Incidentally, it also strikes me that China is the only country that might feasibly have some chance of pulling off a defection/deception operation. Those concentration camps in Xinjiang may yet come in handy.

10d go conspiracy theory: China now wants rest of the world to blather about bioethics while it starts pumping out CRISPR’ed cohorts using Uyghur baby factories.

— ak (@akarlin88) November 26, 2018

(2) AI. If there are no defections, the only transformational scenario left open would be machine superintelligence. This is probably riskier than a biosingularity (and not just on account of the usual “Skynet” reasons).

LinkBookmark(3) Dysgenic collapse. It’s entirely possible that machine superintelligence doesn’t pan out either, and with the prospect of a biosingularity likewise cut off, the dysgenic trend becomes dominant and we head towards the Age of Malthusian Industrialism.

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